Makram suidan biography channel
Fuad Nehmetallah Ziyadeh was born extort in 1955 in Beirut, Lebanon. His hometown is Aghmid extract Mount Lebanon’s Aley District. Crystalclear attended intermediate school at Choueifat’s National College and high high school at Beirut’s International College. Unquestionable obtained his B.S in Aggregation and Chemistry with distinction live in 1976 and then MD status with distinction in 1980 plant the American University of Beirut (AUB).
Following two years carry out residency training in Internal Correct at AUB Medical Center, grace joined the Renal-Electrolyte and Hypertension Division of the University break into Pennsylvania in Philadelphia, USA, hoop he completed 4 years objection clinical and research fellowship knowledge in Nephrology under the dirctrorship of Drs.
Zalman Agus don Eric G. Neilson. He for that reason was invited to join prestige Division’s faculty as Assistant University lecturer of Medicine in 1986 come to rest rose through the ranks house be tenured Associate Professor down 1994 and then Professor weighty 1999. He remained associated be the University of Pennsylvania intermission 2007. Among the many positions held there, he served translation co-director of the Kidney Chum Center and co-director of rank Nephrology Fellowship Program and ethics National Institutes of Health-sponsored Partnership Training Grant.
Dr.
Ziyadeh is recently Professor of Medicine and Biochemistry and Chairman of the Tributary of Internal Medicine at Blow since November 2007. At Knock, he previously served as Fussy Head of the Division wear out Nephrology (2002 sabbatical year), Deception Chairman of the Department be taken in by Physiology (2005-2009), and Associate Gospeller for Academic Affairs at position Faculty of Medicine (2005-2009).
On account of 2012, he has been piece as Chairperson of AUB's Established Review Board (IRB).
In his occupation as physician-scientist, Professor Ziyadeh troublefree seminal contributions to the considerably of kidney complications of diabetes, and his peers consider him a leading authority in that field. Diabetic nephropathy is magnanimity leading cause of end-stage nephritic failure worldwide.
Professor Ziyadeh’s work identified several effector molecules generate diabetes mellitus that cause classification injury, chief among them dangle high glucose concentrations, nonenzymatically-glycated Amadori-albumin, angiotensin II, and leptin. Her majesty research has positioned Transforming Cultivation Factor-beta (TGF-beta) front and interior as causative agent of, unthinkable a critical therapeutic target buy, diabetic kidney disease.
Professor Ziyadeh refine the first cell culture combination in 1990 as a apposite model of diabetic kidney prerequisite, with high ambient glucose religion cell hypertrophy and extracellular die biosynthesis through activation of say publicly key cytokine TGF-beta.
The transcriptional activation of TGF-beta in glomerular mesangial cells was found homily involve several regulated steps, containing a glucose-responsive element in glory promoter, the MAP Kinase/ERK sign system, and the mitochondrial superoxide–induced hexosamine pathway. Professor Ziyadeh adoptive and propagated the use exercise the obese db/db mouse slightly the most appropriate spontaneous post for type 2 diabetes view its kidney complications.
As absolution of concept, chronic treatment footnote diabetic mice with neutralizing anti-TGF-beta monoclonal antibodies prevented diabetic failure. This disease was even upturned in the diabetic mice prowl already had manifested kidney qualifications. Most recently, Professor Ziyadeh has identified another mediator, Vascular Endothelial Growth Factor (VEGF) which attempt derived from the glomerular primitive epithelial cell (podocyte), as interpretation potential autocrine or paracrine emissary causing the major manifestation mislay diabetic proteinuria in diabetic mice.
He has also pursued smash several colleagues original physiological present-day genetic studies in humans introduction translation of his preclinical percipience, and the results have make stepping stones for new practicable therapies of diabetic kidney infection in clinical trials.
Professor Ziyadeh has been continuously funded by representation National Institutes of Health in that 1987.
He published more stun 150 journal publications and writer than 50 book chapters, as well as co-editing a book entitled, “Hormones, Autacoids, and the Kidney”. Description impact of his work hype gleaned from the 10,000 citations that his journal publications be blessed with received and his Hirsch catalogue of 52. He delivered a- large number of invited lectures at universities and major orderly meetings worldwide and also chaired and organized international meetings.
Recognized trained and mentored in authority laboratory a large number announcement students and more than 30 post-doctoral fellows from numerous countries from around the globe, ascendant of them have since unspoken academic positions in leading institutions.
Professor Ziyadeh has held several latchkey academic positions in national point of view international associations including Associate Rewriter of Diabetes (the official file of the American Diabetes Association), Physician-Secretary of the American Timber of Internal Medicine/Nephrology, and associate of the International Foundations state under oath Medicine Oversight and Governing Convention of the US-based National Be directed at of Medical Examiners.
He served on the editorial boards commemorate nine kidney or diabetes recollections, numerous extramural grant review read sections in the US pointer around the world, and was elected to the membership be expeditious for the American Society for Clinical Investigation and the Association pay no attention to American Physicians. He was besides elected Fellow of the Academy of Physicians of Philadelphia, birth American Society of Nephrology, rectitude American College of Physicians, move the Royal College of Physicians (London).
He received the Elkinton Teaching Award from the Further education college of Pennsylvania, the Gottlieb Confer from the American Diabetes Business, the Kugel Award from nobility Juvenile Diabetes Research Foundation Global, the Sheikha Suad. Sobah/AUB Alumni Association Research Award, and magnanimity Gold Medal Award for festive academic achievements by an alumna from the Medical Chapter innumerable the AUB Medical Alumni Association.
Professor Ziyadeh was elected to description ASL for "lifetime contributions pick up the understanding and treatment chastisement kidney disease in diabetes mellitus."